Abstract:
This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs This is a prospective clinical study of the pharmacokinetics allopurinol in dogs naturally infected by naturally infected by naturally infected by naturally infected by naturally infected by naturally infected by naturally infected by naturally infected by naturally infected by naturally infected by naturally infected by naturally infected by Leishmania spLeishmania spLeishmania sp Leishmania sp Leishmania sp . and domiciled . and domiciled . and domiciled . and domiciled . and domiciled . and domiciled . and domiciled . and domiciled with their guardians with their guardians with their guardianswith their guardianswith their guardians with their guardians with their guardians in in an an endemic endemic endemic endemic endemic area for visceral area for visceral area for visceral area for visceral area for visceral area for visceral area for visceral area for visceral area for visceral area for visceral area for visceral area for visceral leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine leishmaniasis (VL). The aim of the study was to determine pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in pharmacokinetic parameters of allopurinol and its metabolite oxypurinol in dogs dogs undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. undergoing treatment for canine visceral leishmaniasis. We evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that e evaluated 11 dogs that underwent clinical and laborator underwent clinical and laborator underwent clinical and laboratorunderwent clinical and laborator underwent clinical and laboratorunderwent clinical and laborator underwent clinical and laborator underwent clinical and laborator underwent clinical and laboratorunderwent clinical and laborator underwent clinical and laborator underwent clinical and laboratorunderwent clinical and laborator y evaluation. y evaluation. y evaluation. y evaluation. y evaluation. y evaluation. For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood For the pharmacokinetic study, blood samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of samples from each dog were collected before and 12 hours after the administration of allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; allopurinol, orally, at a dose of 10mg / kg, times 0 '15', 30 ', 1; 1.5; 2; 2.5; 3; 4; 5; 7; 10; 12 h. 10; 12 h. 10; 12 h. Urine samples Urine samples Urine samples Urine samples Urine samples Urine samples were collected at 0 were collected at 0 were collected at 0were collected at 0were collected at 0 were collected at 0were collected at 0were collected at 0 were collected at 0were collected at 0 were collected at 0-3 h; 3 h; 3 h; 3-6 h; 6 h; 6 h; 6-9 h; 10 9 h; 10 9 h; 10 -12 h 12 hours after after after the drug drug drug drug administration.administration. administration. administration. administration. administration. The most frequent signs he most frequent signs he most frequent signs he most frequent signs he most frequent signs he most frequent signs he most frequent signs he most frequent signs he most frequent signs he most frequent signs he most frequent signs observed i observed i observed iobserved iobserved iobserved in the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs n the clinical evaluation of dogs were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, were lymphadenomegaly, pale pale mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. mucosa and dermatological alterations. Laboratory testsaboratory testsaboratory tests aboratory tests aboratory testsaboratory testsaboratory tests evidenced evidenced evidenced evidenced anemia ianemia ianemia ianemia i anemia ianemia ianemia in 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), n 18.2% (2/11) of the dogs, hyperproteinemia in 45.4% 5/11), hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT hyperglobulinemia in 81.8% (9/11), hypoalbuminemia elevated ALT levels in 18.2% (2/11), levels in 18.2% (2/11), levels in 18.2% (2/11), levels in 18.2% (2/11), levels in 18.2% (2/11), levels in 18.2% (2/11), levels in 18.2% (2/11), levels in 18.2% (2/11), and and high FA high FA high FA high FA high FA high FA values values values in 18.2% (2/11) of in 18.2% (2/11) of in 18.2% (2/11) of in 18.2% (2/11) of in 18.2% (2/11) of in 18.2% (2/11) of in 18.2% (2/11) of in 18.2% (2/11) of in 18.2% (2/11) of the dogs. dogs. dogs. dogs. The urinary The urinary The urinary The urinary The urinary The urinary protein protein -creatinine ratio (UPCcreatinine ratio (UPCcreatinine ratio (UPCcreatinine ratio (UPCcreatinine ratio (UPC creatinine ratio (UPC creatinine ratio (UPC creatinine ratio (UPC creatinine ratio (UPC creatinine ratio (UPC creatinine ratio (UPCcreatinine ratio (UPC) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had ) was altered in 36.4% (4/11) of the dogs, two had borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value.borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value.borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value.borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. borderline values and five results within the normal value. The urinalysis he urinalysishe urinalysis he urinalysishe urinalysishe urinalysishe urinalysis resulted in resulted in resulted in resulted in resulted in resulted in proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/proteinuria in 63.6% (7/11), hematuria 9.1% 1/leukocyturia 27.3% 3/bacteriuria in 63.6% (7/11), ammo bacteriuria in 63.6% (7/11), ammobacteriuria in 63.6% (7/11), ammo bacteriuria in 63.6% (7/11), ammo bacteriuria in 63.6% (7/11), ammobacteriuria in 63.6% (7/11), ammobacteriuria in 63.6% (7/11), ammo bacteriuria in 63.6% (7/11), ammo bacteriuria in 63.6% (7/11), ammobacteriuria in 63.6% (7/11), ammobacteriuria in 63.6% (7/11), ammo bacteriuria in 63.6% (7/11), ammo bacteriuria in 63.6% (7/11), ammobacteriuria in 63.6% (7/11), ammo bacteriuria in 63.6% (7/11), ammonium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous nium urate crystals in 9.1% (1/11), amorphous crystals 9.1% (1/11)crystals 9.1% (1/11)crystals 9.1% (1/11)crystals 9.1% (1/11) crystals 9.1% (1/11) crystals 9.1% (1/11)crystals 9.1% (1/11) crystals 9.1% (1/11) , and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs. and xanthine crystals in 9.1% (1/11) of the dogs.and xanthine crystals in 9.1% (1/11) of the dogs. The results of the The results of the The results of the The results of the The results of the The results of the The results of the The results of the clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis clinical pathology analysis were used were used were usedwere used were used to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment to evaluate the degree of functional impairment the organs affected by t the organs affected by t the organs affected by t the organs affected by t the organs affected by tthe organs affected by tthe organs affected by tthe organs affected by tthe organs affected by tthe organs affected by t the organs affected by tthe organs affected by tthe organs affected by tthe organs affected by the disease in dogs. he disease in dogs.he disease in dogs. he disease in dogs. he disease in dogs.he disease in dogs. he disease in dogs. he disease in dogs. The The concentrationsconcentrations concentrationsconcentrations concentrationsconcentrations concentrations of allopurinol and of allopurinol and of allopurinol and of allopurinol and of allopurinol and of allopurinol and of allopurinol and oxypurinol were oxypurinol were oxypurinol were oxypurinol were oxypurinol were oxypurinol were determindetermindetermin determin determined ed by HPLCby HPLCby HPLCby HPLC by HPLCby HPLC with UV reading with UV readingwith UV reading with UV readingwith UV readingwith UV reading with UV reading technique. The pharmacokinetic technique. The pharmacokinetic technique. The pharmacokinetic technique. The pharmacokinetic technique. The pharmacokinetic technique. The pharmacokinetic technique. The pharmacokinetic technique. The pharmacokinetic technique. The pharmacokinetic technique. The pharmacokinetic parameters found for allopurinol parameters found for allopurinol parameters found for allopurinol parameters found for allopurinol parameters found for allopurinol parameters found for allopurinol parameters found for allopurinol parameters found for allopurinol parameters found for allopurinol parameters found for allopurinol were were were were Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 Cmax of 6.00 ± 1.78 μg/mL, Tmax 1.50 0.67 h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per h, Kel of 0.31 ± 0.17 per and and Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The Vd/F/kg of 1.37 ± 0.83 L/Kg. The clearanceclearance clearance clearance interval interval interval interval interval interval (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, (Cl) was 0.35 ± 0.11 L/h/kg, and the area under curve (AUC)and the area under curve (AUC) and the area under curve (AUC) and the area under curve (AUC)and the area under curve (AUC)and the area under curve (AUC)and the area under curve (AUC)and the area under curve (AUC)and the area under curve (AUC)and the area under curve (AUC) and the area under curve (AUC) and the area under curve (AUC) and the area under curve (AUC)and the area under curve (AUC) and the area under curve (AUC)and the area under curve (AUC)and the area under curve (AUC) and the area under curve (AUC) was 27.20 ± 7.80 was 27.20 ± 7.80 was 27.20 ± 7.80 was 27.20 ± 7.80 was 27.20 ± 7.80 h*μg/mL. h*μg/mL. h*μg/mL. h*μg/mL. h*μg/mL. The values f The values fThe values fThe values f The values f The values for oxypurinolor oxypurinol or oxypurinol or oxypurinolor oxypurinol were were were were CmaCma x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax x of 3.08 ± 0.68 μg / mL, mean Tmax 5.90 ± 3.60 h 5.90 ± 3.60 h 5.90 ± 3.60 h 5.90 ± 3.60 h, and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. and the area under curve of 33.87 ± 13.10 h*μg/mL. Thus, the Thus, the averageaverage average average values values of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which of the pharmacokinetic data obtained for dogs with leishmaniasis, which were mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, wwere mostly between stages I and II of the disease, w were mostly between stages I and II of the disease, close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the ere close to those described in the literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. literature for healthy dogs. We can We can We can We can We can We can conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of conclude that for dogs in mild or controlled stages of disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease, the pharmacokinetics of allopurinol behave as in healthy dogs. disease, the pharmacokinetics of allopurinol behave as in healthy dogs.disease,